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- Original Article
- Clinical Characteristics of Type 2 Diabetes in Children and Adolescents
- Seong Yong Lee, Choong Ho Shin, Sei Won Yang
- Clin Exp Pediatr. 2002;45(6):754-763. Published online June 15, 2002
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Purpose : The incidence of type 2 diabetes in children and adolescents has been reported to increase recently. The aim of this study is to investigate the clinical features of type 2 diabetes developing during childhood and adolescent period. Methods : The medical records of 33 patients with type 2 diabetes were reviewed. We analysed clinical manifestations, demographic data, and modes... -
- Type 2 Diabetes Mellitus in Children
- Jee Min Park, Eun Gyong Yoo, Duk Hee Kim
- Clin Exp Pediatr. 2002;45(5):646-653. Published online May 15, 2002
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Purpose : The incidence of type 2 diabetes mellitus in children has been increasing worldwide recently, which is thought to be related to the increasing prevalence of obesity. We investigated to evaluate the incidence and the characteristics of type 2 diabetes mellitus in children and also analysed the relationship between intrauterine growth retardation and type 2 diabetes mellitus. Methods :... -
- The Relationship of Maternal Disorder with Neonatal Cord Blood Leptin - Preeclampsia, Diabetes Mellitus, Antenatal Steroid Treatment -
- Seon Mi Park, Eun Young Kim, Yeong Bong Park, Sang Kee Park
- Clin Exp Pediatr. 2001;44(10):1119-1126. Published online October 15, 2001
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Purpose : Leptin, the product of the ob gene is primarily by adipose tissue but also by the human placenta. Leptin may also have a role as a regulator of fetal growth and development during normal pregnancy as well as in pregnancies associated with anomalous fetal growth. Our study aimed to discover whether or not leptin concentration in neonatal cord... -
- Factors Related to the Development of Microalbuminuria in Children and Adolescents with Type 1 Diabetes Mellitus
- Min Ho Jung, Pei Tai Wan, Choong Ho Shin, Sei Won Yang
- Clin Exp Pediatr. 2001;44(5):577-586. Published online May 15, 2001
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Purpose : We observed the prevalence rate of microalbuminuria(MA) and its relationship with the various clinical factors in children and adolescents with type 1 diabetes mellitus(DM). Methods : Seventy two children and adolescents(26 males and 46 females, 17.1±3.0 years) were included. MA was defined as 24 hour urine microalbumin >30mg/day(20μg/min). Subjects were classified into three groups(normoalbuminuria, transient MA, or persistent MA).... -
- Clinical Evaluation of Hypoglycemic Symptoms Reported by Children with Insulin-dependent Diabetes Mellitus and by Their Parents
- Byeong Eul Lee, Hwa Young Park, Cheong Mi Cheon, Eun Kyeong Kwon, Seung Mee Song, Jung Sim Kim, Dong Kyu Jin
- Clin Exp Pediatr. 2001;44(4):450-455. Published online April 15, 2001
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Purpose : The following study has been carried out to find the symptoms of hypoglycemia and the symptoms of transient focal neurologic deficit, which were complained by insulin dependent diabetes mellitus patients and their parents. Methods : The subjects of this study were 16 insulin dependent diabetic patients who were admitted to the pediatric department of Samsung Medical Center. From the... -
- The Clinical Types and Characteristics of Diabetes Mellitus in Korean Children
- Eun Gyong Yoo, Hye Jung Shin, Duk Hi Kim
- Clin Exp Pediatr. 2000;43(12):1591-1598. Published online December 15, 2000
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Purpose : Diabetic children should be classified into type 1 or 2 for adequate diabetic control. However, there is a shortage of information of the appropriate criteria in Korea. This study is desinged to discover the clinical types and characteristics of diabetes mellitus(DM) in Korean children. Methods : We studied the clinical characteristics and laboratory findings of 177 diabetic children. Classification... -
- Factors Influencing the Onset of Honeymoon Period in Children with Type I Diabetes Mellitus
- Jin Soon Hwang, Sei Won Yang
- Clin Exp Pediatr. 2000;43(8):1106-1110. Published online August 15, 2000
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Purpose : Type I diabetes mellitus(DM) is an autoimmune disease which decreases insulin secretion of pancreatic β-cell. The honeymoon period in type I DM is known to be related to the partial recovery of C-peptide and preservation of pancreatic β-cell function. The aim of this study was to determine factors influencing the onset of honeymoon period in children with type... -
- Serum Leptin Levels in Children with Type I Diabetes Mellitus
- Eun Sil Lee, Han Ku Moon, Yong Hoon Park, Yong Woon Kim
- Clin Exp Pediatr. 2000;43(4):550-555. Published online April 15, 2000
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Purpose : Leptin is a highly hydrophobic 16-kDa protein encoded by the ob gene which is expre- ssed in adipocytes and participates in the regulation of food intake and energy expenditure. The aims of the present study were to examine the comparison of leptin levels between type I diabetes mellitus(DM) patients who received exogenous insulin therapy and healthy children, and... -
- Central Diabetes Insipidus in Children Related to Craniotomy for a Brain Tumor
- Seung Mi Song, Eun Jung Park, Jung Sim Kim, Hong Hoe Koo, Mun Hyang Lee, Hyung Jin Shin, Dong Kyu Jin
- Clin Exp Pediatr. 1999;42(12):1702-1710. Published online December 15, 1999
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Purpose : Diabetes insipidus(DI) has been known to be a relatively common complication after craniotomy. We have investigated the incidence and clinical course of DI in children related to craniotomy for a brain tumor and determined the risk factors of postoperative DI. Methods : Sixty-two pediatric patients, who have undergone craniotomy for a brain tumor(including stereotactic biopsy) from February 1995 through... -
- Usefulness of Minimal Model Analysis : Measurement of Insulin Sensitivity, Glucose Effectiveness, and Insulin Secretory Capacity from Pancreatic Islet Cells in Children with Simple Obesity or Type 2 Diabetes Mellitus
- Se Young Kim, Sei Won Yang
- Clin Exp Pediatr. 1999;42(4):561-570. Published online April 15, 1999
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Purpose : It is known that insulin resistance and compensatory hyperinsulinemia from pancreatic islet cells to overcome insulin resistance could develop in children with simple obesity. When insulin resistance is aggravated by decompensation of high insulin secretion, obese children frequently progress to overt type 2 diabetes mellitus(DM). The purpose of the present study was to measure insulin sensitivity, glucose effectiveness,... -
- Anthropometric Measurement of Newborn in Women with Gestational Diabetes Mellitus
- Kyung Hoon Kang, Seong Won Yang, Hye Kyung Han, Woo Gill Lee, Mi Na Lee, Hak Chul Jang, Il Soon Hwang, Eun Sung Kim
- Clin Exp Pediatr. 1999;42(3):339-347. Published online March 15, 1999
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Purpose : To find the anthropometric characteristics of newborn in women with gestational diabetes mellitus(GDM), and the relationship between the birth weight and anthropometric measurements of newborn, maternal body habitus and glycemic control in GDM group. Methods : Maternal weight, height, and obstetric history of 82 women with GDM and 93 women with normal glucose tolerance were recorded at the... -
- Case Report
- A Case of Polyglandular Autoimmune Syndrome
- Kyung Ah Choi, Ji Yeoun Kang, Chul Hoe Koo, Wha Mo Lee, Young Suk Jeon
- Clin Exp Pediatr. 1998;41(9):1299-1303. Published online September 15, 1998
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When dysfunction of two or more endocrine glands occurs in association with circulating organ specific antibodies directed against the involved glands, the term polyglandular autoimmune(PGA) syndrome is applied. This syndrome is usually classified into three groups. The autoimmune nature of this disease has been based on the presence of lymphocytic infiltration of the affected glands, organ specific autoantibody in serum,... -
- Original Article
- Growth Status and Levels of Growth Factors in Children with Insulin-dependent Diabetes Mellitus
- So Chung Chung, Duk Hee Kim
- Clin Exp Pediatr. 1998;41(8):1102-1110. Published online August 15, 1998
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Purpose : It is well known that the linear growth velocity in children with insulin-dependent diabetes mellitus(type 1 DM) is closely related to metabolic control and onset age of the disease. Many studies have demonstrated growth impairment in children with type 1 DM, regardless of the degree of metabolic control, whereas other studies have found no growth retardation. Therefore, we... -
- Case Report
- A Case of Familial Hypercholesterolemia with Diabetes Mellitus
- Yong Kyu Sohn, Kee Young Chang, Kee Hyoung Lee, Young Chang Tockgo
- Clin Exp Pediatr. 1997;40(6):862-866. Published online June 15, 1997
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Familial Hypercholesterolemia is the most common hyperlipoproteinemia during the childhood, which occurs from the mutation of genes that regulates low-density lipoproteins(LDL), and is classified into two types, the homozygote presented abnormal genes from both parents and the heterozygote presented an abnormal gene from each parent. Type IIa familial hypercholesterolemia is characterized by, especially, increased level of LDL which is common type and normal level... -
- A Case of Mauriac's syndrome
- Se Young Kim, Choong Ho Shin, Il Soo Ha, Hae Il Cheong, Sei Won Yang, Yong Choi, Hyung Ro Moon
- Clin Exp Pediatr. 1996;39(7):1020-1024. Published online July 15, 1996
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Mauriac's syndrome was described in the 1920s, as a triad of poorly controlled insulin dependent diabetes mellitus, profound growth retardation, and hepatomgaly. Following the wide availability of insulin and intensification of diabetic control, this entity has become quite rare. A 9-year-old female child was transferred to pediatric OPD of SNUCH because of hyperglycemia, short stature, and visual disturbance. Five years prior to admission, she... -
- Acanthosis Nigricans and TypeII Diabetes in Childhood
- In Na Jeong, Hyung Ro Moon
- Clin Exp Pediatr. 1996;39(3):404-410. Published online March 15, 1996
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The authors report two cases of type II diabetes with and without a acanthosis nigricans in children and a case of obese child with acanthosis nigricans encountered at Seoul Eul Ji Hospital in 1994 with review of literatures on relationship of obesity, acanthosis nigricans and type II diabetes. In case 1, 14-year old girl, BMI was 24 (weight, 63.5Kg ; height,... -
- Original Article
- Characteristics of Childhood Diabetes
- Mi Jung Park, Wook Chang, Hyun Chul Lee, Duk Hi Kim, Ho Seoung Kim
- Clin Exp Pediatr. 1995;38(8):1116-1123. Published online August 15, 1995
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Purpose : Because of weternized life style, environmental air pollution and infection, the incidence of childhood diabetes is increasing daily. This study was attempted to evaluate charateristics of childhood diabetes. Methods : We evaluated 117 patients diagnosed with Diabetes at Yonsei and Ewha University College of medicine from 1985 to 1994. Results : 1) The majority of patients were diagnosed as IDDM(86%).... -
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- Sex Hormone Binding Globulin Levels in Children with Insulin Dependent Diabetes Mellitus
- Duk Hi Kim, Mi Jung Park, Ho Sung Kim
- Clin Exp Pediatr. 1995;38(7):963-969. Published online July 15, 1995
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Purpose : Sex hormone binding globulin(SHBG) is produced in liver and binds to testostero-ne and estradiol. Plasma SHBG levels are increased by estrogen and thyrotoxicosis and decreased by testostrone, insulin, growth hormone, prolactin, obesity and noninsulin dependent diabetes mellitus. SHBG levels in patients with NIDDM is known to be higher than normal, but SHBG levels in children with IDDM is controversial.... -
- Clinical Study on Insulin Dependent Diabetes mellitus
- Seog Beom Cho, Kwang Rae Lee, Chang Beom Shin, Oh Kyung Lee, Chong Duk Kim, Oh Kyung Lee
- Clin Exp Pediatr. 1995;38(6):827-834. Published online June 15, 1995
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Purpose : Insulin dependet diabetes mellitus(IDDM) is a rare disease in children, but it will progress rapidly and falls into a diabetic ketoacidosis or coma. Unfortunately, the characteristics and prevalence rate of children with IDDM are not well known in Korea. With a view to recognizing its importance, we studied clinical course of IDDM patients in Chonbuk province, Korea. Methods : From... -
- Case Report
- A Case of Diabetes Mellitus due to Hemochromatosis in Patient with CPRCA
- Eun Hee Kim, Yong Hwa, Ho Sik, Sung Wom Kim
- Clin Exp Pediatr. 1995;38(2):280-284. Published online February 15, 1995
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Iron overload from repeated blood transfusions in patients with hematologic problems is a problem of clinical significance, because eventually it can lead to secondary hemochromatosis with diabetes. So it is important to diagnose iron overload early and to restrict blood transfusions in these patients. Recently, we experienced one case of secondary hemochromatosis with diabetes in patient wi th congenital pure red... -
- Original Article
- Body Composition of Children and Adolescents with Insulin-dependetn Diabetes Mellitus
- Hye Young Kang, Mi Jung Park, Duk Hi Kim, You Kyung Park, Jong Ho Lee, Ho Seong Kim
- Clin Exp Pediatr. 1994;37(12):1709-1716. Published online December 15, 1994
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Bodycomposition measurement is useful in the diagnosis of pathoogy, assessment of disease process and response to treatment in many endoclonologic and metabolic diseases. The Techniques used currently are mostly indirect, often expensive, difficult and time-consuming. A new method for estimation of body composition, infrared interactance, is rapid, safe, noninvasive, and may be useful in research ad clinical studies. Body composition was... -
- The Growth Hormone-Binding Proteins in Human Serum: Partial characterization and Regulation
- Ji Young Suh, Bu Hun Lee, Jeh Hoon Shin, Hang Lee, Seong Ryul Jang
- Clin Exp Pediatr. 1994;37(10):1427-1436. Published online October 15, 1994
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We assessed abotu growth homone binding proteins(GHP|BP) activity which was measured eluted biotin GH fraction with alkaline phosphatase-streptavidine in children with insulin dependent diabetes mellitus(IDDM), short stature due to growth hormone deficiency(GHD), chronic renal failure, short stature due to nutritional deficiency. Hypothyroidism, and noraml control groups using high pressure liquid chromatography protein pak 300 sw column. The following results are observed: 1)... -
- Case Report
- A Case of Miescher Syndrome with Insulin-Resistant Diabetes Mellitus
- Byung Min Choi, Jong Kwang Lee, Kee Hwan Yoo, Joo Won Lee, Soon Kyum Kim
- Clin Exp Pediatr. 1994;37(9):1292-1295. Published online September 15, 1994
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Miescher syndrome comprises congenital acanthosis nigricans, hypertrichosis, failure to thrive and short stature, dysmorphism especially of the jaws and oral cavity. Insulin-resistant diabetes mellitus, and a characteristic general appearance. This report concerns a rare case of 12-year-old girl having insulin resistant diabetic mellitus with Miescher syndrome. The relevant literature was reviewed. -
- Original Article
- Prevalence of Diabetes Mellitus and Glycosuria in School children
- Jae Ho Lee, Kwang Wook Ko
- Clin Exp Pediatr. 1994;37(7):986-993. Published online July 15, 1994
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An epidemiological survey on the glycosuria was conducted on the senier students of middle and hign school in Seoul, from March 1981 to March 1982. Selected examinee totalled to 254,835 of which 138,116 were male & 116,719 were female. The initial, second and third urine sugar test were done with Combur-test strip? Glucose tolerance test was performed on those who... -
- Case Report
- A Case of Prader-Willi Syndrome with Diabetes Mellitus
- Hee Ran Choi, Eun Ha Choi, Seong Hee Jang, Young Min Ahn
- Clin Exp Pediatr. 1994;37(4):565-572. Published online April 15, 1994
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Prader-Willi syndrome is characterized by infantile hypotonia, mental retardation, hyperhagia, hypogonadism and obestiy. Approximately 60% of all PLW syndrome show an interstitial deletion of chromosome 15, 37% have apparently normal chromosome, and 3.6% have a variety of other abnormalities involving chromosome 15. Diabetes mellitus has been considered a component of PLW syndrome and the incidence is about 7%. We... -
- A case of Central Diabetes Insipidus Associated with Brachycephaly
- Woo Sik Kang, Mee Kyung Namgoong, Jae Seung Yang, Baek Keun Lim, Jong Soo Kim
- Clin Exp Pediatr. 1994;37(2):282-287. Published online February 15, 1994
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Brachyecphaly is a kind of craniosynostosis. Because of premature closure of the coronal suture, the skull is shorter in the anteroposterior diameter but is widened with a high vault and the occiput and borehead are flattened. Diabetes insipidus had been reported in oxycephaly. We have experienced a case of central diabetes insipidus associated with brachcephaly. A brief review of related literatures... -
- A Case of Holoprosencephaly, Alobar Type
- Kyu Sun CHoi, Kang Seo Park, Young Tack Jang, Wan Seob Kim
- Clin Exp Pediatr. 1992;35(3):390-394. Published online March 15, 1992
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A case of Holoprosencephaly, alobar type , was presented here and 13-month follow-up has been made. He had dyspnea, polikilothermia, frequent atypical seizures, hypernatremia & pitressinresponsive Diabetes insipidus as clinical manifeststions. Chromosome studies showed normal male karyotype (46XY). The diagnosis was confirmed by brain CT scan. A brief review of the related literature was made. -
- Original Article
- A case of transient diabetes mellitus and diabetic ketoacidosis induced by L-asparaginase and prednisolone administration in a patient with relapsed acute lymphocytic leukemia.
- Won Kyu Choi, Mee Kyung Namgoong, Har Yong Lee, Hwang Min Kim, Jong Soo Kim
- Clin Exp Pediatr. 1991;34(9):1316-1322. Published online September 30, 1991
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L-asparaginase is known as an effective anticancer drug in the induction chemotherapy of acute lymphocytic leukemia. The side effects or toxicities of L-asparaginase and prednisolone are hypersen- sitivity reaction, hepatotoxicity, pancreatitis and transient diabetes mellitus, CNS toxicity, disorder of coagulation system and mild cytotoxicity. We experienced a case of transient diabetes mellitus and diabetic ketoacidosis induced by L- asparaginase, prednisolone, vincristine and MTX administration in... -
- A case of nephrogenic diabetes insipidus due to vesicoureteral reflux.
- Yong Bae Suh, Jong Yul Jeon, Sung Ho Cha, Byoung Soo Cho, Chang Il Ahn
- Clin Exp Pediatr. 1991;34(9):1299-1304. Published online September 30, 1991
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Nephrogenic diabetes insipidus is a disorder characterized by polydipsia and polyuria resulting from failure of the renal tubules and collecting ducts to respond to antidiuretic hormone despite elevated blood levels of antidiuretic hormone. We experienced a case of nephrogenic diabetes insipidus in 13 months-old girl probably secondary to vesicoureteral reflux grade IV. The clinical manifestations were extreme thirst, polydipsia and polyuria. Family history was nonspecific and... -
- The effect of pertussis vaccine on streptozotocin induced diabetic rats.
- Kyung Rae Moon, Kwang Rhun Koo, Sang Kee Park, Yeong Bong Park, Byoung Rai Lee, Keun Hong Kee
- Clin Exp Pediatr. 1991;34(7):897-906. Published online July 31, 1991
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Streptozotocin produces diabetes in laboratory animals through the destuction of the pancreatic beta cells. The diabetogenic activity of STZ, however, is known to be modified by several agents such as nicotinamide, diazoxide, adrenergic blockers and petussis vaccine (PV). The present study was undertaken to observe the protective effect of PV or boiled pertussis vaccine (bPV; incubating the PV at 80 C for 30 mintues)... -
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